Nocker R E, Schoonbrood D F, van de Graaf E A, Hack C E, Lutter R, Jansen H M, Out T A
Department of Pulmonology, University of Amsterdam, The Netherlands.
Int Arch Allergy Immunol. 1996 Feb;109(2):183-91. doi: 10.1159/000237218.
We have investigated whether IL-8 is present in airway secretions from patients with asthma and chronic obstructive pulmonary disease (COPD) to obtain information on its possible role in airway inflammation in obstructive airways disease. In the bronchoalveolar lavage fluid (BALF) from 11 clinically stable patients with asthma the levels of IL-8 were increased compared to 10 healthy subjects (median: controls 21.5 pg/ml, asthma 244 pg/ml: p < 0.005). In the patients with asthma the levels of IL-8 correlated with the percentage neutrophils in the BALF (r = 0.81; p < 0.001) and with a parameter of the permeability of the respiratory membrane, the quotient (alpha 2-macroglobulin in BALF)/(alpha 2-macroglobulin in serum) (r = 0.66; p < 0.025). In the sputum sol phase of 9 patients with symptomatic asthma the levels of IL-8 were lower than in 9 patients with COPD (asthma: 6.4 ng/ml; COPD: 16.3 ng/ml; p < 0.02) and significantly correlated with those of neutrophilic myeloperoxidase (MPO; r = 0.85; p < 0.005). The increased levels of IL-8 in the airway secretions from both patients with asthma and COPD may be markers of an ongoing inflammatory process, which is more pronounced in patients with COPD. In patients with asthma the strong correlation between the levels of IL-8 and the percentage neutrophils and/or the levels of MPO points to a role of IL-8 in the recruitment and activation of neutrophils in the airway lumen.
我们研究了哮喘和慢性阻塞性肺疾病（COPD）患者气道分泌物中是否存在白细胞介素-8（IL-8），以获取其在阻塞性气道疾病气道炎症中可能作用的相关信息。与10名健康受试者相比，11名临床稳定的哮喘患者支气管肺泡灌洗液（BALF）中的IL-8水平升高（中位数：对照组21.5 pg/ml，哮喘组244 pg/ml：p<0.005）。在哮喘患者中，IL-8水平与BALF中中性粒细胞百分比相关（r = 0.81；p<0.001），并与呼吸膜通透性参数（BALF中α2-巨球蛋白）/（血清中α2-巨球蛋白）相关（r = 0.66；p<0.025）。在9名有症状哮喘患者的痰液溶解相中，IL-8水平低于9名COPD患者（哮喘：6.4 ng/ml；COPD：16.3 ng/ml；p<0.02），且与嗜中性粒细胞髓过氧化物酶（MPO）水平显著相关（r = 0.85；p<0.005）。哮喘和COPD患者气道分泌物中IL-8水平升高可能是正在进行的炎症过程的标志物，在COPD患者中更为明显。在哮喘患者中，IL-8水平与中性粒细胞百分比和/或MPO水平之间的强相关性表明IL-8在气道腔内中性粒细胞的募集和激活中起作用。
