Hiwatashi N, Yao T, Watanabe H, Hosoda S, Kobayashi K, Saito T, Terano A, Shimoyama T, Muto T
Third Department of Internal Medicine, Tohoku University School of Medicine, Miyagi, Japan.
J Gastroenterol. 1995 Nov;30 Suppl 8:13-6.
To clarify the long-term prognosis of Japanese patients with ulcerative colitis, we investigated the cumulative colectomy rate and the survival rate, and compared the results with reports from Western countries. The subjects were 778 patients who had visited 8 hospitals from 1973 to 1990. A total of 114 of the 778 patients (14.7%) had required colectomy and 21 (2.7%) had died. These rates were higher in the patients who had total colitis, and in those who had acute fulminant type of severe type. There were no significant differences in these rates according to age of onset (under 29 years, 30-49 years, and more than 50 years). The cumulative colectomy rate increased rapidly within 2 years after onset. Thereafter, the rate increased gradually, by 1%-2% per year. In patients with total colitis, 14.1% required colectomy within 2 years. The age at onset had no effect on this rate. The cumulative survival rate decreased gradually throughout the first 10 years, the rate being 96.2% in the 10th year. No deaths occurred in the 11-18th years after onset. Despite our inclusion of more patients with total or severe colitis, our results were similar to or slightly superior to those reported from Western countries; this may be attributed to a temporal bias.
为明确日本溃疡性结肠炎患者的长期预后，我们调查了累计结肠切除术率和生存率，并将结果与西方国家的报告进行了比较。研究对象为1973年至1990年间就诊于8家医院的778例患者。778例患者中共有114例（14.7%）需要进行结肠切除术，21例（2.7%）死亡。全结肠炎患者以及急性暴发型重症患者的这些比率更高。根据发病年龄（29岁以下、30 - 49岁和50岁以上），这些比率无显著差异。累计结肠切除术率在发病后2年内迅速上升。此后，该比率逐年逐渐上升，每年上升1% - 2%。全结肠炎患者中，14.1%在2年内需要进行结肠切除术。发病年龄对此比率无影响。累计生存率在最初10年内逐渐下降，第10年时为96.2%。发病后11 - 18年无死亡病例。尽管我们纳入了更多全结肠炎或重症结肠炎患者，但我们的结果与西方国家报告的结果相似或略优；这可能归因于时间偏倚。
