Iida M, Yao T, Okada M
Department of Medicine, Kawasaki Medical School, Kurashiki, Japan.
J Gastroenterol. 1995 Nov;30 Suppl 8:17-9.
Two hundred and three patients with Crohn's disease seen at Kyushu University, Fukuoka University, and their affiliated centers from 1973 to 1988 were followed for 4.4 +/- 3.2 years (mean +/- SD), to evaluate the prognosis relative to life span and surgery. Cumulative survival rate and cumulative operation rate were calculated by the life table method. Cumulative survival rates 5 and 10 years after diagnosis were 98.9% and 98.9%, respectively; these figures were not different from the expected survival rates in the sex-and age-matched general population. Cumulative operation rates 5 and 10 years after the onset of symptoms were 16.2% and 39.1%, respectively, In a second study, we investigated 419 patients with Crohn's disease, diagnosed at nine institutions from 1975 to 1990. The follow-up period was 6.3 +/- 3.9 years and the information was obtained from mailed questionnaires. Cumulative survival rates 5 and 10 years after diagnosis were 99.2% and 96.9%, respectively. Cumulative operation rates 5 and 10 years after the onset of symptoms were 30.3% and 70.8%, respectively. These results indicate that the prognosis of Japanese patients with Crohn's disease may be superior to that reported in Western countries.
1973年至1988年期间，在九州大学、福冈大学及其附属医院就诊的203例克罗恩病患者接受了4.4±3.2年（平均±标准差）的随访，以评估与寿命和手术相关的预后。采用寿命表法计算累积生存率和累积手术率。诊断后5年和10年的累积生存率分别为98.9%和98.9%；这些数字与性别和年龄匹配的普通人群的预期生存率没有差异。症状出现后5年和10年的累积手术率分别为16.2%和39.1%。在第二项研究中，我们调查了1975年至1990年期间在9家机构诊断的419例克罗恩病患者。随访期为6.3±3.9年，信息通过邮寄问卷获得。诊断后5年和10年的累积生存率分别为99.2%和96.9%。症状出现后5年和10年的累积手术率分别为30.3%和70.8%。这些结果表明，日本克罗恩病患者的预后可能优于西方国家报道的预后。
