抗艾滋病药物——十九。新雷公藤红素，一种从雷公藤中提取的新型抗HIV成分：分离与结构解析。
Anti-AIDS agents--XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.
作者信息
Chen K, Shi Q, Fujioka T, Nakano T, Hu C Q, Jin J Q, Kilkuskie R E, Lee K H
机构信息
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.
出版信息
Bioorg Med Chem. 1995 Oct;3(10):1345-8. doi: 10.1016/0968-0896(95)00114-v.
A new kaurane type diterpene lactone, neotripterifordin (1), has been isolated from the roots of Tripterygium wilfordii. The structure of 1 was elucidated by spectroscopic methods, which included the concerted application of a number of 2-D NMR techniques including 1H-1H COSY, phase-sensitive NOESY, HETCOR, and long-range HETCOR. Compound 1 showed potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.
从雷公藤根中分离出一种新的贝壳杉烷型二萜内酯，新雷公藤红素（1）。通过光谱方法阐明了1的结构，这些方法包括协同应用多种二维核磁共振技术，如1H-1H COSY、相敏NOESY、HETCOR和远程HETCOR。化合物1在H9淋巴细胞中显示出有效的抗HIV复制活性，EC50为25 nM，TI为125。
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