抗艾滋病药物，4. 雷公藤红素，一种从雷公藤中提取的新型抗HIV成分：分离与结构解析。
Anti-AIDS agents, 4. Tripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.
作者信息
Chen K, Shi Q A, Fujioka T, Zhang D C, Hu C Q, Jin J Q, Kilkuskie R E, Lee K H
机构信息
Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
出版信息
J Nat Prod. 1992 Jan;55(1):88-92. doi: 10.1021/np50079a013.
A new kaurane-type diterpene lactone, tripterifordin [1], has been isolated from the roots of Tripterygium wilfordii. The structure of 1 was elucidated by spectroscopic methods, including the concerted application of a number of 2D nmr techniques that involved the 1H-1H COSY, heteronucleus-detected variants of the heteronuclear chemical shift correlation (HETCOR), phase-sensitive NOESY, and long-range HETCOR. Compound 1 shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1 microgram/ml.
从雷公藤根中分离出一种新的贝壳杉烷型二萜内酯，雷公藤内酯醇[1]。通过光谱方法阐明了化合物1的结构，包括协同应用多种二维核磁共振技术，其中涉及1H-1H COSY、异核化学位移相关（HETCOR）的异核检测变体、相敏NOESY和远程HETCOR。化合物1在H9淋巴细胞中显示出抗HIV复制活性，EC50为1微克/毫升。
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