Ciprandi G, Pronzato C, Ricca V, Varese P, Del Giacco G S, Canonica G W
Department of Internal Medicine, University of Genoa, Italy.
Clin Exp Allergy. 1995 Sep;25(9):871-8. doi: 10.1111/j.1365-2222.1995.tb00030.x.
Rhinoconjunctivitis caused by pollen allergy is characterized by typical signs and symptoms and mucosal infiltration by inflammatory cells during the pollen season. It has recently been demonstrated that the adhesion molecule system is deeply involved in cell-to-cell interaction during the inflammatory response which follows allergic reactions.
The aim of the present study (placebo-controlled, double-blind, randomized) was the evaluation of the antiallergic activity of Terfenadine in the model of the allergic rhinitis due to natural pollen exposure.
Two groups of patients with pollen allergy were enrolled in this study. Ten patients were treated with Terfenadine (120 mg/die) for 7 days and 10 with placebo. Evaluation criteria were: (a) clinical: signs and symptoms (recorded daily in a diary card by patients); (b) cytological: inflammatory cell count (neutrophils, eosinophils, metachromatic cells) from nasal lavage at T0 and T7; (c) immunocytochemical: ICAM-1/CD54 expression on nasal epithelial cells at T0 and T7; and (d) mediators dosage (ECP-MPO) on nasal lavage at T0 and T7.
As opposed to the placebo group, patients treated with Terfenadine showed a significant improvement of both symptoms (P < 0.022) and signs P < 0.001), a significant reduction of inflammatory cells infiltrate (P < 0.005), of ECP levels (P < 0.002) and ICAM-1 expression on nasal epithelial cells (P < 0.005).
In conclusion, these data demonstrate that Terfenadine exerts antiallergic activity since it is able to reduce inflammatory cell infiltrate and downregulates ICAM-1 expression.
花粉过敏引起的鼻结膜炎的特征是在花粉季节出现典型的体征和症状以及炎症细胞的黏膜浸润。最近已证明，黏附分子系统在过敏反应后的炎症反应过程中的细胞间相互作用中起重要作用。
本研究（安慰剂对照、双盲、随机）的目的是评估特非那定在自然花粉暴露引起的过敏性鼻炎模型中的抗过敏活性。
两组花粉过敏患者纳入本研究。10例患者接受特非那定（120mg/天）治疗7天，10例接受安慰剂治疗。评估标准为：（a）临床：体征和症状（患者每日记录在日记卡中）；（b）细胞学：T0和T7时鼻灌洗液中的炎症细胞计数（中性粒细胞、嗜酸性粒细胞、异染细胞）；（c）免疫细胞化学：T0和T7时鼻上皮细胞上ICAM-1/CD54的表达；以及（d）T0和T7时鼻灌洗液中的介质剂量（ECP-MPO）。
与安慰剂组相比，接受特非那定治疗的患者症状（P<0.022）和体征（P<0.001）均有显著改善，炎症细胞浸润（P<0.005）、ECP水平（P<0.002）和鼻上皮细胞上ICAM-1表达（P<0.005）均显著降低。
总之，这些数据表明特非那定具有抗过敏活性，因为它能够减少炎症细胞浸润并下调ICAM-1表达。
