Ciprandi G, Pronzato C, Ricca V, Bagnasco M, Canonica G W
Department of Internal Medicine, University of Genoa, Italy.
J Allergy Clin Immunol. 1994 Oct;94(4):738-46. doi: 10.1016/0091-6749(94)90182-1.
Rhinoconjunctivitis caused by pollen allergy is characterized by typical signs and symptoms and mucosal infiltration by inflammatory cells during pollen season. It has been recently demonstrated that the adhesion molecule system is deeply involved in cell-to-cell interaction during inflammatory response consequent to allergic reactions. The aim of this study was to evaluate the expression of intercellular adhesion molecule-1 (ICAM-1 or CD54) on nasal epithelial cells, before and during natural seasonal exposure, in 10 allergic patients (Parietaria judaica-sensitized) and in 10 healthy volunteers, correlating this parameter with clinical and cytologic involvement. Nasal epithelial cells of allergic subjects showed a significant expression of CD54 during pollen season (p < 0.001). On the contrary, no CD54 expression was observed out of pollen season. In healthy volunteers no CD54 expression was observed both before and during pollen season. Cytologic evaluation demonstrated an infiltration by eosinophils (mainly activated [EG2+]), (p < 0.001), neutrophils (p < 0.001), and metachromatic cells (p < 0.001) during pollen season only in allergic subjects. Therefore results indicate that seasonal allergic rhinitis is characterized by an infiltration of inflammatory cells correlated with CD54 expression on nasal epithelial cells. This phenomenon is specific, being restricted only to allergic patients during pollen season.
花粉过敏引起的变应性鼻结膜炎的特征是在花粉季节出现典型的体征和症状以及炎性细胞的黏膜浸润。最近有研究表明，黏附分子系统在过敏反应引发的炎症反应过程中的细胞间相互作用中起重要作用。本研究的目的是评估10名变应性患者（对墙草属致敏）和10名健康志愿者在自然季节暴露之前和期间鼻上皮细胞上细胞间黏附分子-1（ICAM-1或CD54）的表达，并将该参数与临床和细胞学受累情况相关联。变应性受试者的鼻上皮细胞在花粉季节期间CD54表达显著（p < 0.001）。相反，在花粉季节之外未观察到CD54表达。在健康志愿者中，在花粉季节之前和期间均未观察到CD54表达。细胞学评估显示，仅在变应性受试者的花粉季节期间有嗜酸性粒细胞（主要是活化的[EG2+]）浸润（p < 0.001）、中性粒细胞浸润（p < 0.001）和异染细胞浸润（p < 0.001）。因此，结果表明季节性变应性鼻炎的特征是炎性细胞浸润与鼻上皮细胞上的CD54表达相关。这种现象具有特异性，仅在花粉季节期间局限于变应性患者。
