Aslanides I M, Reinstein D Z, Silverman R H, Lazzaro D R, Rondeau M J, Rodriguez H S, Coleman D J
Department of Ophthalmology, Cornell University Medical College, New York, NY 10021, USA.
CLAO J. 1995 Oct;21(4):268-72.
High frequency (50-MHz) ultrasound allows greater resolution (approximately 30 microns) and improved tissue differentiation of the anterior ocular structures than conventional (8-10 MHz) ultrasonic techniques. Spectral analysis of tissue acoustic backscatter is sensitive to both the concentration and size of tissue inhomogeneities. We studied the healing process of experimentally induced corneal scars using high frequency ultrasound spectral analysis. Scatterer size and concentration parameter images of scarred corneas showed distinctive patterns that were correlated with histology over time. This quantitative technique offers a new, noninvasive, in vivo method for the assessment of the internal microarchitecture of surgically altered corneal tissue and its healing dynamics.
与传统的（8 - 10兆赫）超声技术相比，高频（50兆赫）超声能实现更高的分辨率（约30微米），并能更好地分辨眼前部结构的组织差异。组织声学反向散射的频谱分析对组织不均匀性的浓度和大小都很敏感。我们使用高频超声频谱分析研究了实验诱导的角膜瘢痕的愈合过程。瘢痕角膜的散射体大小和浓度参数图像显示出独特的模式，这些模式随时间与组织学相关。这种定量技术为评估手术改变的角膜组织的内部微观结构及其愈合动态提供了一种新的、非侵入性的体内方法。
