Hughes J R, Erhardt C C, Clement M
Department of Dermatology, King's College Hospital, London, UK.
Clin Exp Dermatol. 1995 Mar;20(2):168-70. doi: 10.1111/j.1365-2230.1995.tb02676.x.
Extra-articular involvement of the skin in patients with rheumatoid arthritis is not uncommon. A patient with this condition is reported who developed an unusual cutaneous eruption associated with systemic upset. Skin biopsy showed a dense dermal neutrophilic infiltrate and after treatment with standard immunosuppressive agents had failed he responded to dapsone. The rash recurred on withdrawal of the dapsone but has responded to sulphamethoxypyridamine. It is proposed that this condition is a rare but specific entity of unknown cause associated with rheumatoid arthritis.
类风湿关节炎患者出现关节外皮肤受累的情况并不少见。本文报道了一名患有这种疾病的患者，他出现了一种与全身不适相关的不寻常皮肤疹。皮肤活检显示真皮有密集的嗜中性粒细胞浸润，在标准免疫抑制剂治疗无效后，他对氨苯砜有反应。停用氨苯砜后皮疹复发，但对磺胺甲氧吡哒嗪有反应。有人提出，这种情况是一种与类风湿关节炎相关的病因不明的罕见但特定的病症。
