肺结核中的全身性免疫激活：与HIV感染的共同激活。
Generalized immune activation in pulmonary tuberculosis: co-activation with HIV infection.
作者信息
Vanham G, Edmonds K, Qing L, Hom D, Toossi Z, Jones B, Daley C L, Huebner B, Kestens L, Gigase P, Ellner J J
机构信息
Department of Infection and Immunity, Institute of Tropical Medicine, Antwerpen, Belgium.
出版信息
Clin Exp Immunol. 1996 Jan;103(1):30-4. doi: 10.1046/j.1365-2249.1996.907600.x.
Parameters of immune activation/differentiation were studied in a group of newly diagnosed HIV- and HIV+ pulmonary tuberculosis (TB) patients. Compared with controls, HLA-DR expression on both CD4 and CD8 T cells from the HIV- TB patients was approximately doubled; HLA-DR on T cells from the HIV+ group was tripled. The monocytes from both groups of patients expressed abnormally high levels of the Fc gamma receptors I and III. Serum levels of tumour necrosis factor-alpha (TNF-alpha), neopterin and beta 2-microglobulin were increased in HIV- and even more so in HIV+ TB patients. The expression of HLA-DR on T cell subsets and of Fc gamma R on monocytes correlated with each other, but not with serum activation markers. This pattern of non-specific activation during TB infection may be associated with enhanced susceptibility to HIV infection.
在一组新诊断的HIV阴性和HIV阳性肺结核（TB）患者中研究了免疫激活/分化参数。与对照组相比，HIV阴性肺结核患者的CD4和CD8 T细胞上HLA-DR的表达约增加了一倍；HIV阳性组T细胞上的HLA-DR增加了两倍。两组患者的单核细胞均异常高水平表达Fcγ受体I和III。HIV阴性肺结核患者血清肿瘤坏死因子-α（TNF-α）、新蝶呤和β2-微球蛋白水平升高，HIV阳性肺结核患者升高更明显。T细胞亚群上HLA-DR的表达与单核细胞上FcγR的表达相互相关，但与血清激活标志物无关。肺结核感染期间这种非特异性激活模式可能与HIV感染易感性增加有关。
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