Naim J O, Ippolito K M, Lanzafame R J, van Oss C J
Department of Surgery, Rochester General Hospital, NY, USA.
Curr Top Microbiol Immunol. 1996;210:103-11. doi: 10.1007/978-3-642-85226-8_11.
The Dark Agouti (DA) rat has been shown recently to have a high susceptibility for developing arthritis when challenged with either heterologous or homologous collagen II mixed with mineral oil, or with mineral oil challenge alone. This study determined the arthritogenic potential of silicone gel by either mixing it with bovine collagen II (BII) or by injecting silicone gel alone in DA rats. The incidence of collagen induced arthritis was as follows: PBS group- 0/10, silicone gel group- 4/10, and IFA group- 8/9. Anti-BII antibodies were formed in most of the rats treated with either silicone gel or IFA and these groups of rats showed a positive DTH reaction. The PBS treated rats were negative for both anti-BII antibodies and DTH reaction. The incidence of arthritis formation in rats injected with silicone gel alone was 0/10, while the IFA injected rats showed an incidence of 8/10. Silicone gel taken from a commercial breast implant thus is capable of mediating collagen induced arthritis in the DA rat. However, silicone gel alone does not appear to be arthritogenic.
最近研究表明，黑褐家鼠（DA大鼠）在受到与矿物油混合的异源或同源II型胶原蛋白攻击，或仅受到矿物油攻击时，极易患关节炎。本研究通过将硅胶与牛II型胶原蛋白（BII）混合，或仅在DA大鼠中注射硅胶，来测定硅胶的致关节炎潜力。胶原蛋白诱导性关节炎的发病率如下：PBS组为0/10，硅胶组为4/10，不完全弗氏佐剂（IFA）组为8/9。大多数接受硅胶或IFA治疗的大鼠体内形成了抗BII抗体，且这些大鼠组表现出阳性迟发型超敏反应（DTH反应）。经PBS处理的大鼠抗BII抗体和DTH反应均为阴性。单独注射硅胶的大鼠关节炎形成率为0/10，而注射IFA的大鼠发病率为8/10。因此，从市售隆胸植入物中取出的硅胶能够在DA大鼠中介导胶原蛋白诱导性关节炎。然而，单独的硅胶似乎不具有致关节炎性。
