Naim J O, Ippolito K M, Lanzafame R J, van Oss C J
Department of Surgery, Rochester General Hospital, NY 14621, USA.
J Autoimmun. 1995 Oct;8(5):751-61. doi: 10.1006/jaut.1995.0056.
The relative safety (or otherwise) of silicone gel filled breast implants remains a controversial issue. The Dark Agouti (DA) rat has been shown recently to have a high susceptibility for developing arthritis. This study determined the arthritogenic potential of silicone gel, silicone oil, and the low molecular weight octamethylcyclotetrasiloxane (D4), by either mixing it with bovine collagen II (BII) or by injecting silicone gel alone in DA rats. Three separate experiments were performed using 110 female DA rats with 10 rats per treatment group. The incidence of collagen induced arthritis was as follows: Experiment I (6 micrograms BII)- PBS = 0/10, silicone gel = 4/10, and IFA = 8/9; Experiment II (125 micrograms BII)- PBS = 0/10, silicone gel = 7/10, IFA = 10/10, 1,000 cs silicone oil = 3/10, D4 = 0/10, and 1% D4 in 1,000 cs silicone oil = 1/10; Experiment III (adjuvant alone)-IFA = 8/10, silicone gel = 0/10. Anti-BII antibodies were formed in most of the rats treated with either silicone gel or IFA mixed with BII and these groups of rats showed a positive DTH reaction. The PBS treated rats were negative for both anti-BII antibodies and DTH reaction. Silicone gel taken from a commercial breast implant thus is capable of mediating collagen induced arthritis in the DA rat. However, silicone gel alone does not appear to be arthritogenic.
硅胶填充乳房植入物的相对安全性（或其他方面）仍然是一个有争议的问题。最近发现黑褐大鼠（DA大鼠）对患关节炎的易感性很高。本研究通过将硅胶、硅油和低分子量八甲基环四硅氧烷（D4）与牛II型胶原蛋白（BII）混合或单独向DA大鼠注射硅胶，来确定它们的致关节炎潜力。使用110只雌性DA大鼠进行了三个独立实验，每个治疗组10只大鼠。胶原蛋白诱导的关节炎发病率如下：实验I（6微克BII）- 磷酸盐缓冲液（PBS）=0/10，硅胶=4/10，不完全弗氏佐剂（IFA）=8/9；实验II（125微克BII）- PBS =0/10，硅胶=7/10，IFA =10/10，1000厘沲硅油=3/10，D4 =0/10，1000厘沲硅油中1% D4 =1/10；实验III（仅佐剂）- IFA =8/10，硅胶=0/10。大多数用硅胶或与BII混合的IFA处理的大鼠形成了抗BII抗体，并且这些大鼠组表现出阳性迟发型超敏反应（DTH反应）。PBS处理的大鼠抗BII抗体和DTH反应均为阴性。因此，从商业乳房植入物中取出的硅胶能够在DA大鼠中介导胶原蛋白诱导的关节炎。然而，单独的硅胶似乎不具有致关节炎性。
