Bridges A J, Anderson J D, Burns D E, Kemple K, Kaplan J D, Lorden T
Department of Medicine, University of Wisconsin Hospital and Clinics, William S. Middleton Memorial Veterans Hospital, Madison 53705, USA.
Curr Top Microbiol Immunol. 1996;210:277-82. doi: 10.1007/978-3-642-85226-8_28.
We assessed the prevalence of autoantibodies in women with silicone implants and controls. Five hundred consecutive patients with silicone implants, 25 age-matched normal women, 25 women with silicone implants and no rheumatic symptoms, and 100 women with fibromyalgia were tested. Immunofluorescence antinuclear antibodies (ANA) were performed using HEp-2 cells. Subtype autoantibodies were performed by enzyme-linked immunoassay and Western blot. ANA tests were positive in 30% of patients with silicone implants and rheumatic symptoms, 8% of age-matched normal women, 28% of women with silicone implants without clinical symptoms, and 25% of women with fibromyalgia and no silicone implants. The predominant ANA pattern was speckled (55%). ANA subtype testing was positive in 4.8% of patients and none of the controls. We conclude that a larger proportion of women with silicone implants have autoantibodies compared to age-matched asymptomatic women suggesting immune activation in women with silicone implants.
我们评估了植入硅胶的女性及对照组中自身抗体的患病率。对连续500例植入硅胶的患者、25例年龄匹配的正常女性、25例植入硅胶且无风湿症状的女性以及100例纤维肌痛女性进行了检测。使用HEp-2细胞进行免疫荧光抗核抗体（ANA）检测。通过酶联免疫吸附测定和蛋白质印迹法检测自身抗体亚型。植入硅胶且有风湿症状的患者中30%的ANA检测呈阳性，年龄匹配的正常女性中8%呈阳性，植入硅胶但无临床症状的女性中28%呈阳性，有纤维肌痛但未植入硅胶的女性中25%呈阳性。主要的ANA模式为斑点型（55%）。患者中4.8%的ANA亚型检测呈阳性，对照组均为阴性。我们得出结论，与年龄匹配的无症状女性相比，植入硅胶的女性中有更大比例存在自身抗体，这表明植入硅胶的女性存在免疫激活。
