Teuber S S, Saunders R L, Halpern G M, Brucker R F, Conte V, Goldman B D, Winger E E, Wood W G, Gershwin M E
Department of Internal Medicine, University of California, Davis, School of Medicine 95616, USA.
Curr Top Microbiol Immunol. 1996;210:59-65. doi: 10.1007/978-3-642-85226-8_6.
The metabolic fate of silicone gel leaked into the body from an implant is unknown. In this study, serum from 72 women with silicone gel breast implants and 55 control women was blindly assayed by inductively coupled plasma atomic emission spectroscopy (ICP-AES) for elemental silicon. Samples were processed using materials free of silicon. The mean silicon level in controls was 0.13 +/- 0.07 mg/l (range 0.06-0.35 mg/l), while in implant patients, the mean was significantly higher at 0.28 +/- 0.22 mg/l (range 0.06-0.87 mg/l) (P < 0.01, Student's t-test with correction for unequal variances). Using the mean of the control group + 2 SD as a cutoff for normal range (0.27 mg/l), 25/72 (34.7%) implant patients exceeded this value, compared with 2/55 (3.6%) controls. There was no significant correlation between past rupture of one or both implants, current rupture at the time of the blood draw or the number of years with implants and silicon levels. The results suggest that elevations of serum silicon are seen in many women with silicone gel breast implants. The kinetics of this elevation and the actual chemical species of the measured silicon remain to be determined.
从植入物渗漏到体内的硅胶的代谢转归尚不清楚。在本研究中，采用电感耦合等离子体原子发射光谱法（ICP-AES）对72例硅胶乳房植入物女性和55例对照女性的血清进行盲法检测，以测定元素硅含量。样本处理使用不含硅的材料。对照组的平均硅水平为0.13±0.07mg/l（范围0.06 - 0.35mg/l），而植入物患者组的平均水平显著更高，为0.28±0.22mg/l（范围0.06 - 0.87mg/l）（P < 0.01，采用方差不齐校正的学生t检验）。以对照组均值 + 2标准差作为正常范围的临界值（0.27mg/l），72例植入物患者中有25例（34.7%）超过该值，而55例对照组中仅有2例（3.6%）超过。一侧或双侧植入物既往破裂、采血时的当前破裂情况或植入物使用年限与硅水平之间均无显著相关性。结果表明，许多硅胶乳房植入物女性的血清硅水平会升高。这种升高的动力学以及所测硅的实际化学形态仍有待确定。
