通过荧光原位杂交将人类功能性β-葡萄糖醛酸酶基因（GUSB）定位到7q11.21→q11.22，并将两个假基因定位到5p13和5q13。
Localization by fluorescence in situ hybridization of the human functional beta-glucuronidase gene (GUSB) to 7q11.21 --> q11.22 and two pseudogenes to 5p13 and 5q13.
作者信息
Speleman F, Vervoort R, van Roy N, Liebaers I, Sly W S, Lissens W
机构信息
Department of Medical Genetics, University Hospital Ghent, Belgium.
出版信息
Cytogenet Cell Genet. 1996;72(1):53-5. doi: 10.1159/000134161.
The gene coding for human beta-glucuronidase (GUSB) was mapped to 7q11.21 --> q11.22 by fluorescence in situ hybridization (FISH), thus clarifying the contradictory published localizations of this gene. Multiple unprocessed pseudogenes and pseudogene fragments for GUSB have been described. However, only two weak signals, one at chromosome band 5p13 and the other at 5q13, could be detected with FISH, suggesting considerable divergence between GUSB and its related sequences.
通过荧光原位杂交（FISH）技术，编码人类β-葡萄糖醛酸酶（GUSB）的基因被定位到7q11.21 --> q11.22，从而澄清了该基因此前相互矛盾的定位报道。已报道了多个未加工的GUSB假基因和假基因片段。然而，通过FISH仅能检测到两个微弱信号，一个位于染色体5p13带，另一个位于5q13，这表明GUSB与其相关序列之间存在显著差异。
Zotero 插件