[The preliminary study of insulin resistance in pregnancy induced hypertension].

OBJECTIVE

To observe the changes of glucose metabolism in late pregnancy and to reveal the relationship between insulin resistance and pregnancy induced hypertension (PIH).

METHODS

The 75g oral glucose tolerance test (OGTT) was performed in 30 cases with PIH (37-41 weeks gestation), 30 cases of normal pregnancy and 12 non-pregnant women. The levels of serum glucose, insulin and C-peptide were measured by radioimmunoassay, and the areas under the curve (AUC) were calculated.

RESULTS

There were significant increases of the peak level or AUC of insulin in PIH (61.42 +/- 48.72, 137.12 +/- 81.12 mIU/L) and in normal pregnant group (70.46 +/- 58.42, 150.37 +/- 104.76 mIU/L) compared with non-pregnant controls (17.12 +/- 11.03, 34.38 +/- 16.01 mIU/L) (P < 0.01), however, they had a similar glucose levels before or after GTT (P > 0.05). Furthermore, there was no correlationship between systolic or diastolic blood pressure and the fasting insulin or the AUC.

CONCLUSIONS

Insulin resistance and hyperinsulinemia were found in late pregnancy, but the changes of insulin resistance in PIH cases was not significant. So, there was no definitive relationship between insulin resistance and the rising of blood bressure of PIH.