Zhang K, Wu Z, Ding M
Weifang Women and Children Health Care Institute, Shandong Province.
Zhonghua Fu Chan Ke Za Zhi. 1995 Aug;30(8):467-70.
To observe the changes of glucose metabolism in late pregnancy and to reveal the relationship between insulin resistance and pregnancy induced hypertension (PIH).
The 75g oral glucose tolerance test (OGTT) was performed in 30 cases with PIH (37-41 weeks gestation), 30 cases of normal pregnancy and 12 non-pregnant women. The levels of serum glucose, insulin and C-peptide were measured by radioimmunoassay, and the areas under the curve (AUC) were calculated.
There were significant increases of the peak level or AUC of insulin in PIH (61.42 +/- 48.72, 137.12 +/- 81.12 mIU/L) and in normal pregnant group (70.46 +/- 58.42, 150.37 +/- 104.76 mIU/L) compared with non-pregnant controls (17.12 +/- 11.03, 34.38 +/- 16.01 mIU/L) (P < 0.01), however, they had a similar glucose levels before or after GTT (P > 0.05). Furthermore, there was no correlationship between systolic or diastolic blood pressure and the fasting insulin or the AUC.
Insulin resistance and hyperinsulinemia were found in late pregnancy, but the changes of insulin resistance in PIH cases was not significant. So, there was no definitive relationship between insulin resistance and the rising of blood bressure of PIH.
观察妊娠晚期糖代谢变化，揭示胰岛素抵抗与妊娠高血压综合征（PIH）之间的关系。
对30例PIH患者（妊娠37 - 41周）、30例正常孕妇及12例非孕妇女进行75g口服葡萄糖耐量试验（OGTT）。采用放射免疫分析法测定血清葡萄糖、胰岛素和C肽水平，并计算曲线下面积（AUC）。
与非孕对照组（17.12±11.03，34.38±16.01 mIU/L）相比，PIH组（61.42±48.72，137.12±81.12 mIU/L）和正常妊娠组（70.46±58.×42，150.37±104.76 mIU/L）胰岛素峰值水平或AUC显著升高（P < 0.01），然而，她们在糖耐量试验前后血糖水平相似（P > 0.05）。此外，收缩压或舒张压与空腹胰岛素或AUC之间无相关性。
妊娠晚期存在胰岛素抵抗和高胰岛素血症，但PIH患者胰岛素抵抗变化不显著。因此，胰岛素抵抗与PIH血压升高之间无明确关系。
