Duro F, Condorelli P, Pappalardo G
Farmaco Sci. 1977 Mar;32(3):173-9.
The synthesis of 3-phenyl-10-methyl-2,3-dihydropyridazine[4,5-b] [1,4]benzothiazin-1,4(10H)-dione (I) and the 2 phenyl siomer-(II) is described. The compounds were prepared by the reaction of 2-methylaminothiophenol with 1,2-dihydro-20phenyl-4,5-dibromopyridazin-3,6-dione in an alkaline aqueous/alcoholic medium. The structure of the two isomers was demonstrated by transformation of (I) into 3-phenyl-10-methyl-3H-pyridazino[4,5-b] [1,4]benzothiazin-4(10H)-one (IV) reported in the literature.
描述了3-苯基-10-甲基-2,3-二氢哒嗪并[4,5-b][1,4]苯并噻嗪-1,4(10H)-二酮（I）和2-苯基异构体（II）的合成。这些化合物是通过2-甲基氨基硫酚与1,2-二氢-2-苯基-4,5-二溴哒嗪-3,6-二酮在碱性水/醇介质中反应制备的。通过将（I）转化为文献中报道的3-苯基-10-甲基-3H-哒嗪并[4,5-b][1,4]苯并噻嗪-4(10H)-酮（IV），证明了这两种异构体的结构。
