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[2,3-二氮杂吩噻嗪的合成。十二。2-苯基和3-苯基-10-甲基-2,3-二氢哒嗪并/4,5-b//1,4/苯并噻嗪-1,4(10H)-二酮的二烷基氨基烷基衍生物]

[Synthesis of 2,3-diazaphenothiazine. XII. Dialkylaminoalkylic derivatives of 2-phenyl and 3-phenyl-10-methyl-2,3-dihydropyridazino/4,5-b/ /1,4/benzothiazin-1,4 (10 H)-dione].

作者信息

Condorelli P, Pappalardo G, Duro F

出版信息

Farmaco Sci. 1977 Jul;32(7):531-8.

PMID:891908
Abstract

The alkylation with methyl iodide and methyl sulfate of 2-phenyl-10-methyl-2,3-dihydropyridazino [4,5-b] [1,4]benzothiazin-1,4(10H)-dione (A) and the corresponding 3-phenyl substituted isomer (B) has been studied. Some derivatives of (A) and (B) substituted at the O atom with dialkyaminoalkyl groups are described; these have been subjected to pharmacological testing.

摘要

对2-苯基-10-甲基-2,3-二氢哒嗪并[4,5-b][1,4]苯并噻嗪-1,4(10H)-二酮(A)和相应的3-苯基取代异构体(B)用碘甲烷和硫酸二甲酯进行烷基化反应进行了研究。描述了一些在O原子上被二烷基氨基烷基取代的(A)和(B)的衍生物;这些衍生物已经进行了药理测试。

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