Condorelli P, Pappalardo G, Duro F
Farmaco Sci. 1977 Jul;32(7):531-8.
The alkylation with methyl iodide and methyl sulfate of 2-phenyl-10-methyl-2,3-dihydropyridazino [4,5-b] [1,4]benzothiazin-1,4(10H)-dione (A) and the corresponding 3-phenyl substituted isomer (B) has been studied. Some derivatives of (A) and (B) substituted at the O atom with dialkyaminoalkyl groups are described; these have been subjected to pharmacological testing.
对2-苯基-10-甲基-2,3-二氢哒嗪并[4,5-b][1,4]苯并噻嗪-1,4(10H)-二酮(A)和相应的3-苯基取代异构体(B)用碘甲烷和硫酸二甲酯进行烷基化反应进行了研究。描述了一些在O原子上被二烷基氨基烷基取代的(A)和(B)的衍生物;这些衍生物已经进行了药理测试。