Sallet G, Amoaku W M, Lafaut B A, Brabant P, De Laey J J
University Hospital Ghent, Belgium.
Graefes Arch Clin Exp Ophthalmol. 1995 Nov;233(11):677-89. doi: 10.1007/BF00164669.
Fluorescein angiography (FA) has been widely used in the diagnostic evaluation of choroidal tumors. Indocyanine green angiography (ICG-A), which permits better visualization of choroidal vasculature than FA, has been recently introduced into clinical practice. Only few reports exist on the ICG-A characteristics of choroidal tumors.
The fluorescein and indocyanine green angiograms of 61 patients were assessed. These included 14 patients with choroidal nevi, 30 with malignant melanomas, 7 with suspected melanomas or atypical nevi, 5 with hemangiomas and 5 with metastases.
The outline of pigmented tumors was more accurate on ICG-A than on FA. Characteristic patterns were seen in all intra-ocular tumors with ICG-A, so it was possible to distinguish hemangiomas from malignant lesions. Characteristic features of malignant melanomas include abnormal vascular pattern and marginal late dye leakage. None of the benign lesions showed these features. In suspected melanomas, the presence of abnormal choroidal vascular patterns and/or late dye leakage on ICG-A may indicate malignancy.
The study suggests that ICG-A can yield additional information that is useful in differentiating amongst choroidal tumors. Better delineation of pigmented lesions with ICG-A allows more accurate treatment planning and follow-up.
荧光素血管造影（FA）已广泛用于脉络膜肿瘤的诊断评估。吲哚菁绿血管造影（ICG-A）能够比FA更好地显示脉络膜血管系统，最近已被引入临床实践。关于脉络膜肿瘤的ICG-A特征的报道很少。
评估了61例患者的荧光素和吲哚菁绿血管造影图像。其中包括14例脉络膜痣患者、30例恶性黑色素瘤患者、7例疑似黑色素瘤或非典型痣患者、5例血管瘤患者和5例转移瘤患者。
色素性肿瘤的轮廓在ICG-A上比在FA上更精确。在所有眼内肿瘤的ICG-A图像上均可见特征性模式，因此有可能将血管瘤与恶性病变区分开来。恶性黑色素瘤的特征性表现包括异常血管模式和边缘晚期染料渗漏。良性病变均未显示这些特征。在疑似黑色素瘤中，ICG-A上出现异常脉络膜血管模式和/或晚期染料渗漏可能提示恶性。
该研究表明，ICG-A可以提供有助于区分脉络膜肿瘤的额外信息。ICG-A对色素性病变的更好描绘有助于更准确的治疗计划制定和随访。
