对肠胃外淋球菌菌毛疫苗的生殖器抗体反应。
Genital antibody response to a parenteral gonococcal pilus vaccine.
作者信息
McChesney D, Tramont E C, Boslego J W, Ciak J, Sadoff J, Brinton C C
出版信息
Infect Immun. 1982 Jun;36(3):1006-12. doi: 10.1128/iai.36.3.1006-1012.1982.
Abstract
A parenteral gonococcal pilus vaccine which has previously been shown to be safe and antigenic also results in the production of specific local genital antibody. All three major antibody classes were present in the local secretions, but immunoglobulin A predominated, a portion of which is dimeric 11S immunoglobulin A. This mucosal antibody is also capable of blocking the attachment of gonococci to epithelial cells. The antibody cross-reacted with five heterologous pili in a solid-phase radioimmunoassay. These results are encouraging and suggest that a gonococcal pilus vaccine may be efficacious in preventing gonorrhea.
摘要
一种肠胃外淋球菌菌毛疫苗，此前已证明其安全且具有抗原性，它还能促使产生特异性局部生殖器抗体。所有三种主要抗体类型都存在于局部分泌物中，但免疫球蛋白A占主导，其中一部分是二聚体11S免疫球蛋白A。这种黏膜抗体也能够阻止淋球菌附着于上皮细胞。在固相放射免疫测定中，该抗体与五种异源菌毛发生交叉反应。这些结果令人鼓舞，表明淋球菌菌毛疫苗可能对预防淋病有效。
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