Yap E H, Ho T H, Chan Y C, Thong T W, Ng G C, Ho L C, Singh M
Department of Microbiology, Faculty of Medicine, National University of Singapore.
Genitourin Med. 1995 Dec;71(6):402-4. doi: 10.1136/sti.71.6.402.
To evaluate, by seroepidemiology, the possible role of the sexually-transmitted flagellate, Trichomonas vaginalis, in invasive cervical cancer.
Sera from 121 invasive cervical cancer patients and 242 random age-matched female controls. Antibodies to T. vaginalis were detected by the western blot technique.
Antibodies to T. vaginalis were detected in the sera of 41.3% (50/121) of invasive cervical cancer patients compared with only 5.0% (12/242) of female controls. All the reactive sera reacted strongly with the immunogenic surface membrane proteins of T. vaginalis of molecular weights of about 92 and 115 kDa, with variable reactivity to other immunogenic proteins of T. vaginalis.
The significantly increased relative risk, RR = 3.42 (95% CI = 1.73-6.78), is comparable to the RRs derived in seroepidemiological studies of human papillomavirus, suggesting that T. vaginalis may be even more closely associated with invasive cervical cancer than previously realized.
通过血清流行病学评估性传播鞭毛虫阴道毛滴虫在浸润性宫颈癌中可能发挥的作用。
收集121例浸润性宫颈癌患者和242例年龄匹配的随机女性对照的血清。采用免疫印迹技术检测阴道毛滴虫抗体。
浸润性宫颈癌患者血清中阴道毛滴虫抗体的检出率为41.3%（50/121），而女性对照中仅为5.0%（12/242）。所有反应性血清均与分子量约为92和115 kDa的阴道毛滴虫免疫原性表面膜蛋白强烈反应，对阴道毛滴虫的其他免疫原性蛋白反应不一。
相对风险显著增加，RR = 3.42（95%CI = 1.73 - 6.78），与人类乳头瘤病毒血清流行病学研究得出的RR值相当，这表明阴道毛滴虫与浸润性宫颈癌的关联可能比之前认为的更为密切。
