Department of Medical Parasitology, Faculty of Medicine, Mansoura University, 2 El-Gomhouria Street, Mansoura, 35516, Egypt.
Department of Clinical Oncology and Nuclear Medicine, Mansoura University Hospital, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.
Parasitol Res. 2021 Apr;120(4):1379-1388. doi: 10.1007/s00436-020-06942-7. Epub 2020 Nov 7.
Trichomonas vaginalis is one of the most common non-viral sexually transmitted infections (STIs) that has been associated with prostate cancer in some countries. This study aims to investigate if T. vaginalis infection can be a risk factor for prostate cancer in Egypt and its possible relationship with cancer prognostic factors and overall survival. Serum samples were collected from a total of 445 age-matched males; 126 with prostate cancer, 108 with bladder cancer, 91 with different types of cancers, and 120 healthy controls, and then analyzed by ELISA for detection of anti-Trichomonas IgG and prostate-specific antigen (PSA). The results revealed that only 8.3% of controls were seropositive for trichomoniasis, compared with 19% of prostate cancer patients (P = 0.015). There were positive associations between the levels of PSA and tumor stage with T. vaginalis IgG optical density scores among the seropositive cases (P < 0.001 and < 0.05, respectively). However, no significant correlations were detected between seropositivity of T. vaginalis and other prognostic factors or overall survival in those patients. In conclusion, chronic T. vaginalis infection may be associated with prostate cancer, but it does not seem that this STI aggravates the cancer status.
阴道毛滴虫是最常见的非病毒性性传播感染（STI）之一，在一些国家与前列腺癌有关。本研究旨在探讨阴道毛滴虫感染是否是埃及前列腺癌的一个危险因素，以及其与癌症预后因素和总生存的可能关系。共收集了 445 名年龄匹配的男性血清样本；126 名前列腺癌患者、108 名膀胱癌患者、91 名不同类型癌症患者和 120 名健康对照者，然后通过 ELISA 分析检测抗阴道毛滴虫 IgG 和前列腺特异性抗原（PSA）。结果显示，对照组中仅有 8.3%的人血清呈阴道毛滴虫病阳性，而前列腺癌患者中这一比例为 19%（P = 0.015）。在血清阳性病例中，PSA 水平和肿瘤分期与阴道毛滴虫 IgG 光密度评分之间存在正相关（P < 0.001 和 < 0.05）。然而，在这些患者中，阴道毛滴虫血清阳性与其他预后因素或总生存之间未检测到显著相关性。总之，慢性阴道毛滴虫感染可能与前列腺癌有关，但似乎这种性传播感染不会加重癌症状况。
