细胞动力学的随机游走模型。

A random walk model of cellular kinetics.

作者信息

Rogers T D, Sampson J R

出版信息

Int J Biomed Comput. 1977 Jan;8(1):45-60. doi: 10.1016/0020-7101(77)90055-1.

Abstract

The sorting out of biological cell mixtures into clusters of one cell type is modelled as a consequence of random cell and cluster motion, during which cells of like type cohere upon collision. After a description of the model and its motility rules, the results of several computer simulation studies are analysed and compared with both laboratory data and certain theoretical predictions. The model is found to be more biologically realistic than previous models with similar results. Suggestions for further reserach are discussed. An Appendix contains details about the data structures and algorithms employed in the simulation.

摘要

将生物细胞混合物分选成单一细胞类型的簇被建模为随机细胞和簇运动的结果，在此过程中同类细胞在碰撞时会凝聚在一起。在描述了该模型及其运动规则之后，分析了几项计算机模拟研究的结果，并与实验室数据和某些理论预测进行了比较。发现该模型比具有类似结果的先前模型在生物学上更具现实意义。讨论了进一步研究的建议。附录包含了模拟中使用的数据结构和算法的详细信息。