Kano A, Kambara K, Arakawa M, Ando F, Ohno M, Tsuchiya M, Nishigaki K, Fujiwara H
Second Department of Internal Medicine, Gifu University School of Medicine, Japan.
J Appl Physiol (1985). 1995 Oct;79(4):1320-9. doi: 10.1152/jappl.1995.79.4.1320.
We studied the effects of ventilation and pleural effusion on measurements of airway thermal volume (ATV) and pulmonary blood flow (PBF) by using the airway gas thermometry method of V. B. Serikov, M. S. Rumm, K. Kambara, M. I. Bootomo, A. R. Osmack, and N. C. Staub (J. Appl. Physiol. 72: 944-953, 1992) in 39 anesthetized dogs with or without lung edema or pleural effusion. To examine the differential effects of increased-pressure and increased-permeability lung edema on accuracy and sensitivity of ATV and PBF, two models of lung edema were induced by intravenous infusion of a Dextran 70 solution and alloxan monohydrate, respectively. Dogs were hyperventilated for 3 min by using a wide range of minute ventilation (VE) to produce two steady-state conditions of airway temperature. Higher levels of VE increased an estimated amount of ATV. The ATV produced by hyperventilation at VE values of 559, 158, and 72 ml.min-1.kg-1 was consistent with the gravimetric total lung mass, the blood-free wet lung weight, and the extravascular lung water volume, respectively. The coefficient of lung thermal conductivity, a practical index of the rate of heat conduction through tissue from lung vessels, was related to the ratio of the decrease in expired air temperature to VE, and estimated PBF was consistent with the thermodilution cardiac output. Pleural effusion had little effect on measurements of ATV and PBF. However, ATV and PBF showed increased variation in dogs with dextran-induced lung edema.
我们采用V. B. 瑟里科夫、M. S. 拉姆、K. 坎巴拉、M. I. 博托莫、A. R. 奥斯马克和N. C. 施陶布（《应用生理学杂志》72: 944 - 953, 1992年）的气道气体温度测定法，研究了通气和胸腔积液对气道热容量（ATV）和肺血流量（PBF）测量值的影响，实验对象为39只麻醉犬，部分伴有或不伴有肺水肿或胸腔积液。为了检验压力增加型和通透性增加型肺水肿对ATV和PBF准确性及敏感性的不同影响，分别通过静脉输注右旋糖酐70溶液和一水合四氧嘧啶诱导出两种肺水肿模型。通过使用广泛的分钟通气量（VE）使犬过度通气3分钟，以产生两种气道温度的稳态条件。较高水平的VE增加了估计的ATV量。在VE值分别为559、158和72 ml·min⁻¹·kg⁻¹时，过度通气产生的ATV分别与重量法测定的全肺质量、无血湿肺重量和血管外肺水体积一致。肺热传导系数是肺血管组织热传导速率的一个实用指标，与呼气温度下降与VE的比值相关，估计的PBF与热稀释心输出量一致。胸腔积液对ATV和PBF的测量影响很小。然而，在右旋糖酐诱导的肺水肿犬中，ATV和PBF的变化有所增加。
