Serikov V B, Fleming N W, Talalov V A, Stawitcke F A
Children's Hospital Oakland Research Institute, Oakland, CA 94549, USA.
Eur J Appl Physiol. 2004 Mar;91(2-3):314-23. doi: 10.1007/s00421-003-0966-4. Epub 2003 Oct 28.
To investigate the relative role of pulmonary perfusion compared to ventilation on lung heat exchange, we determined the effects of blood flow, tidal volume and frequency of ventilation on the rate of lung heat transfer. In anesthetized dogs and isolated, perfused lungs, we investigated the dependence of the overall lung heat transfer coefficient (HTC) and lung thermal capacitance upon ventilation and pulmonary blood flow. The relationship between the HTC and pulmonary blood flow was strongly dependent on ventilation parameters. A distributed model of non-steady-state heat exchange adequately described these observations and demonstrated that changes in pulmonary blood flow may be considered as changes in the effective conductivity of the bronchial walls as 0.4 (0.1) J s(-1)m(-1) K(-1) per (l/min(-1)) of pulmonary blood flow. Our model describes the complex relationship between HTC, ventilation pattern, and effective thermal conductivity of the bronchial walls, all of which present limitations for the use of lung heat transfer to determine pulmonary blood flow.
为了研究肺灌注与通气相比在肺热交换中的相对作用，我们确定了血流、潮气量和通气频率对肺热传递速率的影响。在麻醉犬和离体灌注肺中，我们研究了整体肺传热系数（HTC）和肺热容量对通气和肺血流量的依赖性。HTC与肺血流量之间的关系强烈依赖于通气参数。非稳态热交换的分布式模型充分描述了这些观察结果，并表明肺血流量的变化可被视为支气管壁有效传导率的变化，即每（升/分钟）肺血流量为0.4（0.1）焦耳·秒⁻¹·米⁻¹·开⁻¹。我们的模型描述了HTC、通气模式和支气管壁有效热导率之间的复杂关系，所有这些都对利用肺热传递来确定肺血流量存在限制。
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