Dickey R P, Gasser R F, Hower J F, Matulich E M, Brown G T
Fertility Institute of New Orleans, New Orleans, Louisiana 70128, USA.
Hum Reprod. 1995 Oct;10(10):2676-9. doi: 10.1093/oxfordjournals.humrep.a135766.
The embryonic period of development is characterized by marked variability in the rate of embryonic growth and development. Differences in uterine blood flow may explain this variability. We investigated the relationship between uterine artery blood flow volume (VOL), uterine artery pulsatility index (UA-PI), uterine artery resistance index (UA-RI), spiral artery pulsatility index (SA-PI), spiral artery resistance index (SA-RI), chorionic sac diameter (CSD), and crown-rump length (CRL) during 321 first trimester vaginal colour Doppler ultrasound examinations of 94 delivered or continuing pregnancies. After correcting for the confounding effect of gestational age, subject, and serum hormone levels by Analysis of Covariance, CRL was related to UA-PI (P = 0.025) and UA-RI (P < 0.001), but not to VOL, SA-PI, or SA-RI. No relationship was found between CSD and any uterine blood flow variables. Serum oestradiol levels were related to CSD and CRL (P < 0.001). No relationship was found to progesterone, maternal age, parity, or previous abortion. We conclude that differences in uterine blood flow and serum oestradiol explain some of the variability in the rate of embryo growth during the first 12 gestational weeks.
胚胎发育时期的特点是胚胎生长发育速度存在显著差异。子宫血流量的差异可能解释了这种变异性。我们在对94例已分娩或继续妊娠的孕妇进行的321次孕早期经阴道彩色多普勒超声检查中，研究了子宫动脉血流量（VOL）、子宫动脉搏动指数（UA-PI）、子宫动脉阻力指数（UA-RI）、螺旋动脉搏动指数（SA-PI）、螺旋动脉阻力指数（SA-RI）、绒毛膜囊直径（CSD）和头臀长度（CRL）之间的关系。通过协方差分析校正孕周、受试者和血清激素水平的混杂效应后，CRL与UA-PI（P = 0.025）和UA-RI（P < 0.001）相关，但与VOL、SA-PI或SA-RI无关。未发现CSD与任何子宫血流变量之间存在关系。血清雌二醇水平与CSD和CRL相关（P < 0.001）。未发现与孕酮、母亲年龄、产次或既往流产存在关系。我们得出结论，子宫血流量和血清雌二醇的差异解释了妊娠前12周胚胎生长速度的部分变异性。
