Jauniaux E, Johnson M R, Jurkovic D, Ramsay B, Campbell S, Meuris S
Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, University of London, United Kingdom.
Obstet Gynecol. 1994 Sep;84(3):338-42.
To evaluate the relation between the development of the uteroplacental circulation as assessed by Doppler velocimetry and the maternal blood relaxin concentration.
Transvaginal color Doppler investigation of the uteroplacental circulation was performed in 42 healthy women at 6-15 weeks' gestation before termination of pregnancy for psychosocial reasons. The resistance index (RI), pulsatility index (PI), and maximum peak velocity were recorded at the level of the main uterine artery, and the presence of intervillous flow was noted. Relaxin, hCG, 17 beta-estradiol (E2), and progesterone levels were measured in maternal venous blood.
Limited intervillous flow was noted from 10 weeks' gestation and continuous intervillous flow from 12 weeks. An inverse relation was observed between the circulating levels of both E2 and progesterone and uterine artery RI and PI, whereas the relaxin level correlated positively with uterine RI and PI. Estradiol and progesterone levels also correlated positively with uterine peak systolic velocity and intervillous blood flow. Multiple linear regression analysis indicated that both hormones contributed to the decrease in downstream resistance to uterine blood flow with advancing gestational age, as assessed by uterine RI. In addition, relaxin contributed to the uterine RI and PI and to the intervillous blood flow.
These data suggest that relaxin, E2, and progesterone may influence the changes in uterine blood flow that occur in early pregnancy. The role played by E2 and progesterone in the development of the uteroplacental circulation may be modulated by relaxin, constituting a novel function for this ovarian peptide.
通过多普勒测速法评估子宫胎盘循环的发育与母体血液中松弛素浓度之间的关系。
对42名因心理社会原因在妊娠6至15周时终止妊娠的健康女性进行经阴道彩色多普勒子宫胎盘循环检查。记录子宫主动脉水平的阻力指数（RI）、搏动指数（PI）和最大峰值速度，并记录绒毛间隙血流情况。检测母体静脉血中松弛素、人绒毛膜促性腺激素（hCG）、17β-雌二醇（E2）和孕酮水平。
妊娠10周时可见有限的绒毛间隙血流，12周时可见持续的绒毛间隙血流。观察到E2和孕酮的循环水平与子宫动脉RI和PI呈负相关，而松弛素水平与子宫RI和PI呈正相关。雌二醇和孕酮水平也与子宫收缩期峰值速度和绒毛间隙血流呈正相关。多元线性回归分析表明，随着孕周增加，这两种激素均导致子宫血流下游阻力降低，这通过子宫RI进行评估。此外，松弛素影响子宫RI和PI以及绒毛间隙血流。
这些数据表明，松弛素、E2和孕酮可能影响妊娠早期子宫血流的变化。E2和孕酮在子宫胎盘循环发育中所起的作用可能受到松弛素的调节，这构成了这种卵巢肽的一种新功能。
