Dalton C F, Laird S M, Serle E, Saravelos H, Warren M A, Li T C, Bolton A E
Biomedical Research Unit, Jessop Hospital for Women, Sheffield, UK.
Hum Reprod. 1995 Oct;10(10):2680-4. doi: 10.1093/oxfordjournals.humrep.a135767.
The concentrations of CA 125 and placental protein 14 (PP14) were measured in uterine flushings obtained throughout the luteal phase of the cycle from eight normal fertile women. The concentrations of both proteins increased in a similar pattern throughout the luteal phase of the cycle, with the most dramatic increase occurring 6 days after their luteinizing hormone surge (day LH +6). However, a greater variation in CA 125 concentrations was seen compared to that seen for PP14. The concentrations were compared to those obtained on day LH +7 of the cycle from a group (n = 35) of women with recurrent miscarriage. The ranges in concentration of PP14 and CA 125 in the flushings of fertile and recurrent miscarriage patients were very similar. However, a greater proportion of women with recurrent miscarriage (55%) had low concentrations (< 5 ng/ml) of PP14 than in the control group (12.5%) and the concentrations of PP14 in the uterine flushings were significantly less (P < 0.05) in women with recurrent miscarriage compared to the normal fertile group. There was no significant difference in the concentration of CA 125 in the uterine flushings between the two groups. Histological observation of the endometrial biopsy samples from recurrent miscarriage patients gave menstrual cycle datings that ranged from day LH +2.5 to LH +6.5 with retarded endometrium (< day LH +5) in 12 of 35 (34%) patients. Of these 12 patients, 10 (83%) had low PP14 concentrations and six (50%) had low CA 125 concentrations in their uterine flushings. In the recurrent miscarriage patients with histologically normal (> or = day LH +5) endometrial development, 10 out of 23 (43%) also had low PP14 concentrations and 8 out of 23 (35%) had low CA 125 in their uterine flushings. The results suggest that PP14 is better than CA 125 as a marker for endometrial function in this group of women. In some cases (52%) the low concentrations of PP14 in the uterine flushings could be explained by retarded endometrial development but for the others the reduction in PP14 concentration in the uterine flushing was not associated with retardation of endometrial development.
在月经周期黄体期，从8名正常可育女性获取子宫冲洗液，测定其中CA 125和胎盘蛋白14（PP14）的浓度。在月经周期黄体期，两种蛋白浓度均以相似模式升高，在促黄体生成素高峰后6天（LH +6天）升高最为显著。然而，与PP14相比，CA 125浓度变化更大。将这些浓度与一组（n = 35）复发性流产女性在月经周期LH +7天测得的浓度进行比较。可育女性和复发性流产患者子宫冲洗液中PP14和CA 125的浓度范围非常相似。然而，复发性流产女性中PP14浓度低（< 5 ng/ml）的比例（55%）高于对照组（12.5%），与正常可育组相比，复发性流产女性子宫冲洗液中PP14浓度显著更低（P < 0.05）。两组子宫冲洗液中CA 125浓度无显著差异。对复发性流产患者子宫内膜活检样本进行组织学观察，月经周期分期为LH +2.5天至LH +6.5天，35例患者中有12例（34%）子宫内膜发育延迟（< LH +5天）。在这其中12例患者中，10例（83%）子宫冲洗液中PP14浓度低，6例（50%）子宫冲洗液中CA 125浓度低。在子宫内膜组织学发育正常（≥ LH +5天）的复发性流产患者中，23例中有10例（4~3%）子宫冲洗液中PP14浓度低，其中8例（35%）子宫冲洗液中CA 125浓度低。结果表明，在这组女性中，作为子宫内膜功能标志物，PP14优于CA 125。在某些情况下（52%），子宫冲洗液中PP14浓度低可由子宫内膜发育延迟解释，但在其他情况下，子宫冲洗液中PP14浓度降低与子宫内膜发育延迟无关。
