Cooper J C, Sharkey A M, McLaren J, Charnock-Jones D S, Smith S K
Department of Obstetrics and Gynaecology, University of Cambridge, Rosie Maternity Hospital, UK.
J Reprod Fertil. 1995 Nov;105(2):205-13. doi: 10.1530/jrf.0.1050205.
Vascular endothelial growth factor is a secreted angiogenic growth factor the mRNA of which is present in the placenta. The mRNA encoding the vascular endothelial growth factor receptor, flt, has also been demonstrated in placenta, with trophoblast appearing to be a novel site of flt expression. We investigated the expression of both vascular endothelial growth factor and flt-like immunoreactivity in first trimester and term placentae. In the first trimester, vascular endothelial growth factor immunoreactivity was localized to placental macrophages (Hofbauer cells), and in decidua, to glandular epithelium and maternal macrophages. In the term placenta, vascular endothelial growth factor immunoreactivity was present in extravillous trophoblast and in extracellular material. Flt immunoreactivity was demonstrated on extravillous trophoblast in first trimester and term, and on Hofbauer cells within placental villi. This complex pattern of both vascular endothelial growth factor and flt-like immunoreactivity suggests that vascular endothelial growth factor may be involved not only in the regulation of placental angiogenesis, but also in trophoblast invasion.
血管内皮生长因子是一种分泌型血管生成生长因子，其信使核糖核酸存在于胎盘中。编码血管内皮生长因子受体flt的信使核糖核酸也已在胎盘中得到证实，滋养层似乎是flt表达的一个新位点。我们研究了早孕和足月胎盘组织中血管内皮生长因子和flt样免疫反应性的表达。在早孕阶段，血管内皮生长因子免疫反应性定位于胎盘巨噬细胞（霍夫鲍尔细胞），在蜕膜中定位于腺上皮和母体巨噬细胞。在足月胎盘中，血管内皮生长因子免疫反应性存在于绒毛外滋养层和细胞外物质中。在早孕和足月时，flt免疫反应性在绒毛外滋养层以及胎盘绒毛内的霍夫鲍尔细胞上均有显示。血管内皮生长因子和flt样免疫反应性的这种复杂模式表明，血管内皮生长因子可能不仅参与胎盘血管生成的调节，还参与滋养层的侵袭。
