Emeis M, Liesenfeld O, Henze G, Meredith S, Schoone G, Stück B
Kinderklinik des Universitätsklinikum Rudolf Virchow, Standort Wedding, Freie Universität Berlin.
Klin Padiatr. 1995 Nov-Dec;207(6):347-9. doi: 10.1055/s-2008-1046566.
We here report the case of a 1 4/12 year old girl with visceral leishmaniasis. Returning from a trip to Mallorca she presented with pancytopenia, splenomegaly and fever and was admitted to hospital with suspected malignancy. Diagnosis was established microscopically from bone marrow smear and confirmed by PCR-assisted amplification of leishmania-specific DNA from peripheral blood. Treatment was conducted with stibogluconate for 25 days. Defervescence and improvement of clinical symptoms was seen after 4 days of treatment. Infection due to Leishmania donovani can be acquired throughout the entire mediterranean area and should therefore be included in the differential diagnosis of suspected malignancies in patients with a history of travel to mediterranean countries. PCR proved to be a sensitive tool for establishing the diagnosis of visceral leishmaniasis.
我们在此报告一例1岁4个月大患内脏利什曼病的女童病例。从马略卡岛旅行归来后，她出现全血细胞减少、脾肿大和发热症状，因疑似恶性肿瘤入院。通过骨髓涂片显微镜检查确诊，并经外周血利什曼原虫特异性DNA的PCR辅助扩增得到证实。用葡萄糖酸锑钠治疗25天。治疗4天后体温下降，临床症状改善。杜氏利什曼原虫感染在整个地中海地区均可获得，因此对于有前往地中海国家旅行史的疑似恶性肿瘤患者，应将其纳入鉴别诊断。PCR被证明是诊断内脏利什曼病的一种敏感工具。
