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恶性高热与劳力性热射病之间联系的本质

On the nature of the link between malignant hyperthermia and exertional heatstroke.

作者信息

Bourdon L, Canini F

机构信息

Centre de Recherces du Service de Santé des Armées, La Tronche, France.

出版信息

Med Hypotheses. 1995 Sep;45(3):268-70. doi: 10.1016/0306-9877(95)90116-7.

DOI:10.1016/0306-9877(95)90116-7
PMID:8569550
Abstract

Malignant hyperthermia (MH) is a rare myopathy inducing severe accident when carriers are exposed to triggering agents. MH susceptibility (MHS) is assessed by pharmacological tests performed on muscle strips. Exertional heat stroke (EHS) is a severe accident occurring during long and strenuous exercise. It has been observed that numerous EHS patients are susceptible to MH according to pharmacological tests. Because most of those EHS-MHS subjects were soldiers, we hypothesize that military duty could select subjects with infraclinical myopathy and therefore would increase the MHS:EHS subject ratio.

摘要

恶性高热(MH)是一种罕见的肌病,当携带者接触触发剂时会引发严重事故。通过对肌肉条进行的药理试验来评估恶性高热易感性(MHS)。劳力性热射病(EHS)是在长时间剧烈运动期间发生的严重事故。据药理试验观察,许多EHS患者对MH易感。由于这些EHS-MHS受试者大多数是士兵,我们推测军事任务可能会筛选出患有亚临床肌病的受试者,因此会增加MHS:EHS受试者比例。

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