新生儿肝炎和肝外胆道闭锁的血清胆汁酸模式。
Serum bile acid patterns in neonatal hepatitis and extrahepatic biliary atresia.
作者信息
Javitt N B, Keating J P, Grand R J, Harris R C
出版信息
J Pediatr. 1977 May;90(5):736-9. doi: 10.1016/s0022-3476(77)81238-9.
Serum bile acid patterns were determined in 31 infants ranging in age from 4 days to 24 weeks. Fifteen infants with extrahepatic biliary atresia had a mean concentration of serum bile acids of 90 microng/ml +/- 47 SD;; 16 infants with neonatal hepatitis had a mean concentration of 60 +/- 35.5 SD. The chenodeoxycholate/cholate ratio was greater than one in 13 infants (87%) with atresia and in 10 infants (66%) with neonatal hepatitis. Except for the tendency of a higher total concentration of serum bile acids in infants with atresia, a single serum bile acid value does not differentiate neonatal hepatitis from extrahepatic biliary atresia. The high proportion of chenodeoxycholate in extrahepatic atresia is different from the pattern in other types of cholestatic disease and may reflect an underlying hepatitis.
对31名年龄在4天至24周的婴儿进行了血清胆汁酸模式测定。15例肝外胆道闭锁婴儿的血清胆汁酸平均浓度为90微克/毫升±47标准差；16例新生儿肝炎婴儿的平均浓度为60±35.5标准差。13例（87%）闭锁婴儿和10例（66%）新生儿肝炎婴儿的鹅去氧胆酸盐/胆酸盐比率大于1。除了闭锁婴儿血清胆汁酸总浓度有较高趋势外，单一血清胆汁酸值不能区分新生儿肝炎和肝外胆道闭锁。肝外闭锁中鹅去氧胆酸盐的高比例不同于其他类型胆汁淤积性疾病的模式，可能反映了潜在的肝炎。
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