Kato M, Funahashi H, Sato Y, Takagi H
Second Department of Surgery, Nagoya University, School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1995 Nov;96(11):766-72.
Autotransplantation of the parathyroid glands by mincing method has been performed to maintain parathyroidal function in patients with thyroid cancer, following total thyroidectomy and parathyroidectomy. The functional recovery of grafted parathyroid glands was studied in matured mongrel dogs histologically and by determining the PTH level and serum P, Ca, and compared three different forms of implant; whole gland, minced parathyroid tissue, and thick slices. The minced parathyroid tissue and thick slices were found to be far superior histologically, and endocrinologically, to the whole gland type of implant, with successful takes. And between two types of implants minced tissue and thick slices, no difference was observed histologically and endocrinologically. On the other hand, it is necessary for shortening the time to prepare implant tissue to get successful reimplantation. The time to prepare minced tissue is very short in comparison with thick slices. Thus our method (minced tissue) is very useful for successful reimplantation of the parathyroids.
对于甲状腺癌患者,在全甲状腺切除及甲状旁腺切除术后,已采用切碎法进行甲状旁腺自体移植以维持甲状旁腺功能。通过组织学方法以及测定甲状旁腺激素(PTH)水平和血清磷、钙,在成年杂种犬中研究移植甲状旁腺的功能恢复情况,并比较了三种不同形式的植入物:全腺体、切碎的甲状旁腺组织和厚切片。结果发现,切碎的甲状旁腺组织和厚切片在组织学和内分泌学方面均远优于全腺体类型的植入物,且植入成功。在切碎组织和厚切片这两种植入物类型之间,在组织学和内分泌学方面未观察到差异。另一方面,为了成功进行再植入,缩短制备植入组织的时间很有必要。与厚切片相比,制备切碎组织的时间非常短。因此,我们的方法(切碎组织)对于甲状旁腺的成功再植入非常有用。