Le Roux P D, Reh T A
Department of Neurosurgery, New York University, New York 10016, USA.
Neurosci Lett. 1995 Sep 22;198(1):5-8. doi: 10.1016/0304-3940(95)11946-t.
Whereas axon growth is limited in the mature mammalian central nervous system (CNS), dendritic remodeling occurs throughout life. Since glia can regulate neurite growth during development, we tested whether glia from the mature CNS differ in their ability to support axon and dendrite growth. Cortical neurons were co-cultured with neonatal or mature astroglial, and dendrite and axon outgrowth quantified after 5DIV using immunohistochemical techniques. Primary dendritic growth was supported equally well by mature and immature astrocytes. By contrast, mature astrocytes demonstrated a reduced ability to support axon growth. We propose that the independent regulation of axon and dendrite growth by astrocytes provides a means by which the mature nervous system may adjust its function to activity and the environment.
虽然轴突生长在成熟的哺乳动物中枢神经系统（CNS）中受到限制，但树突重塑在整个生命过程中都会发生。由于神经胶质细胞在发育过程中可以调节神经突的生长，我们测试了来自成熟中枢神经系统的神经胶质细胞在支持轴突和树突生长的能力上是否存在差异。将皮质神经元与新生或成熟的星形胶质细胞共培养，并在培养5天后使用免疫组织化学技术对树突和轴突的生长进行量化。成熟和未成熟的星形胶质细胞对初级树突生长的支持效果相同。相比之下，成熟的星形胶质细胞支持轴突生长的能力有所下降。我们认为，星形胶质细胞对轴突和树突生长的独立调节提供了一种方式，通过这种方式成熟的神经系统可以根据活动和环境来调整其功能。
