Willemsen-Swinkels S H, Buitelaar J K, Weijnen F G, van Engeland H
Department of Child Psychiatry, University of Utrecht, The Netherlands.
Psychiatry Res. 1995 Oct 16;58(3):203-15. doi: 10.1016/0165-1781(95)02749-m.
In a double-blind, placebo-controlled crossover trial 23 autistic children were treated with a single 40-mg dose of the opiate antagonist naltrexone. Drug effects were monitored by detailed playroom observations, actometers, and parents' checklist ratings (Aberrant Behavior Checklist, social items and target behaviors). Naltrexone treatment failed to produce significant changes in social behavior, but it did reduce irritability and target scores on behavior checklists. The playroom data indicated that naltrexone significantly affected indices of activity and attention.
在一项双盲、安慰剂对照的交叉试验中，23名自闭症儿童接受了单次40毫克剂量的阿片类拮抗剂纳曲酮治疗。通过在游戏室进行详细观察、使用活动计以及家长清单评分（异常行为清单、社交项目和目标行为）来监测药物效果。纳曲酮治疗未能使社交行为产生显著变化，但确实降低了易怒性以及行为清单上的目标得分。游戏室数据表明，纳曲酮对活动和注意力指标有显著影响。
