Szabó L, Somogyi E, Pechy O
Morphol Igazsagugyi Orv Sz. 1977 Feb;17(1):54-63.
Authors report in detail recent achievments the investigation of Duffy's blood group system. Genetics of the system is shortly reviewed. Results of their own population-genetical investigation--carried out on 723 non-related persons by the aid of anti-Fy(a) and anti-Fy(b) serum--are also described. According to the author's data frequency of the phenotype Fy(a+b-)=19,63%, of the phenotype Fy(a+b)=50,91%, and of the phenotype Fy(a-b+)=29.46%. Data of the gene-frequency: Fya=0,451; Fyb=0,549. Presence of the gene Fy(-) was not revealed. The Duffy system--among others--was examined in 299 cases of discussed paternity. In 30 cases (10.3%) paternity was excluded on the base of it. In 31 men (8.29%) out of 374 the paternity cystem. Maximal (theoretical) chance of exclusion calculated from the data got in own investigations: 18.625%. Examined and calculated values of the chance of exclusion in cases of opposed homozygotes (12.26%) and in cases of the lack of characteristics (6.36%) were similar to a suitable degree. Technical problems of the investigation are further discussed. Author recommend the use of the examination of Duffy system in cases of discussed paternity.
作者详细报告了达菲血型系统研究的近期成果。简要回顾了该系统的遗传学。还描述了他们自己对723名无亲缘关系个体借助抗Fy(a)和抗Fy(b)血清进行群体遗传学研究的结果。根据作者的数据,Fy(a+b-)表型的频率为19.63%,Fy(a+b)表型的频率为50.91%,Fy(a-b+)表型的频率为29.46%。基因频率数据为:Fya = 0.451;Fyb = 0.549。未发现Fy(-)基因的存在。在299例有争议的亲子鉴定案例中对达菲系统等进行了检测。基于此,在30例(10.3%)案例中排除了亲子关系。在374名男性中有31名(8.29%)涉及亲子关系鉴定。根据自身研究所得数据计算出的最大(理论)排除几率为:18.625%。在对立纯合子案例(12.26%)和缺乏特征案例(6.36%)中检测和计算的排除几率值在一定程度上相似。进一步讨论了研究的技术问题。作者建议在有争议的亲子鉴定案例中采用达菲系统检测。