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[无结合珠蛋白血症(低结合珠蛋白血症)、其发病率、病因及在亲子鉴定血清学中的意义]

[Ahaptoglobinemia (hypohaptoglobinemia), its incidence, etiology and significance in paternity serology].

作者信息

Rex-Kiss B, Szabó L

出版信息

Morphol Igazsagugyi Orv Sz. 1977 Apr;17(2):139-45.

PMID:876261
Abstract

Frequency of ahaptoglobinaemia (ahp) in adult population (on the base of investigation of 4000 cases) was found 0.225 per cent, in children (on the base of investigation of 119 children younger than 2 years) 0.94 per cent. Frequency of ahp among children younger 4 months 44 per cent. These observations support the hypothesis, on the role of a mutagen allel (Hp2m) in the origin of the ahp. If in cases of discussed paternity in the child ahp was revealed and the Hp constellation of the mother: putative father was: Hp 1--1 X 1--1 or 2--2 X 2--2--provided that the paternity with the testing of other blood-group systems could not be excluded--it's necessary to try to identify the true Hp type of the child--since it might give the possibility for exclusion of paternity.

摘要

在成年人群中(基于对4000例病例的调查)无结合珠蛋白血症(ahp)的发生率为0.225%,在儿童中(基于对119名2岁以下儿童的调查)为0.94%。4个月以下儿童中ahp的发生率为44%。这些观察结果支持了关于诱变等位基因(Hp2m)在ahp起源中作用的假说。如果在讨论的亲子关系案例中发现孩子患有ahp,且母亲的Hp组合:推定父亲的Hp组合为:Hp 1--1 × 1--1或2--2 × 2--2 ,前提是在检测其他血型系统时不能排除亲子关系,那么就有必要尝试确定孩子的真正Hp类型,因为这可能为排除亲子关系提供可能。

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