Jullien D, Prévot G, Wolkenstein P, Roujeau J C, Revuz J
Service de Dermatologie, Hôpital Henri-Mondor, Créteil.
Ann Dermatol Venereol. 1995;122(8):540-2.
Eruptive nevus have been described after severe bullous cutaneous adverse drug reactions. We report herein a berloque-like nevus extension after toxic epidermal necrolysis.
A 23 year-old woman was hospitalized for toxic epidermal necrolysis. A blister was in contact with a nevus. Four months after healing, extension of the nevus was seen on the blister area.
During toxic epidermal necrolysis and healing: 1) cytokines and growth factors are produced favouring nevocytes proliferation; 2) macromolecules are exposed on the wound bed; 3) adhesion molecules are expressed on nevocytes, restricting cell migration on exposed macromolecules. Interaction between matrix macromolecules and adhesion molecules could explain the limitation of nevus extension.
严重大疱性皮肤药物不良反应后可出现发疹性痣。我们在此报告中毒性表皮坏死松解症后出现的类似Berloque痣样扩展。
一名23岁女性因中毒性表皮坏死松解症住院。一个水疱与一个痣接触。愈合4个月后，在水疱区域可见痣的扩展。
在中毒性表皮坏死松解症及愈合过程中：1）产生细胞因子和生长因子，促进痣细胞增殖；2）大分子暴露于创面床；3）痣细胞上表达黏附分子，限制细胞在暴露大分子上的迁移。基质大分子与黏附分子之间的相互作用可解释痣扩展的局限性。
