Hong E, Lopez C
Prostaglandins. 1977 Apr;13(4):691-6. doi: 10.1016/0090-6980(77)90240-4.
Changes in gastric secretion induced by the subcutaneous, intraduodenal or intragastric administration of prostaglandin E 1 (PGE1) were evaluated in pylorus-ligated rats. Subcutaneous and intraduodenal injections produced a dose-related inhibition in both total acid and volume of gastric secretion. Dose-response curves for inhibition obtained by these routes were parallel, although PGE1 was more potent when given subcutaneously. Gastric administration produced a dose-related decrease in acid and an increase in volume. The slope of the dose-response curve for acid inhibition with this route was flatter than with subcutaneous or intraduodenal administrations. The present results suggest that PGE1 inhibits gastric secretion by the same mechanism of action when given subcutaneously or into the duodenum, while the effects observed after gastric administration are consequences of local actions. The difference in potency of PGE1 given subcutaneously and in the duodenum would seem to be due to differences in absorption from the site of administration and/or to a greater metabolism of PGE1 during its absorption from the intestines.
在幽门结扎的大鼠中评估了皮下、十二指肠内或胃内给予前列腺素E1（PGE1）引起的胃分泌变化。皮下注射和十二指肠内注射对胃酸分泌总量和分泌量均产生剂量相关的抑制作用。尽管皮下给予PGE1时效力更强，但通过这些途径获得的抑制作用的剂量反应曲线是平行的。胃内给药导致胃酸分泌剂量相关的减少和分泌量增加。该途径的胃酸抑制剂量反应曲线的斜率比皮下或十二指肠内给药时更平缓。目前的结果表明，皮下或十二指肠内给予PGE1时，其通过相同的作用机制抑制胃分泌，而胃内给药后观察到的效应是局部作用的结果。皮下和十二指肠内给予PGE1效力的差异似乎是由于给药部位吸收的差异和/或PGE1在从肠道吸收过程中更大程度的代谢。
