Akamatsu T, Tsukiya T, Nishimura K, Park C H, Nakazeki T
Department of Mechanical Engineering, Kyoto University, Japan.
Artif Organs. 1995 Jul;19(7):631-4. doi: 10.1111/j.1525-1594.1995.tb02393.x.
We have been developing a centrifugal blood pump with a magnetically suspended impeller. To improve pump efficiency, we investigated the pump performances of many kinds of impeller vanes and diffusers, as well as the flow in the gap between the impeller discs and the pump housing. We found the vanes and the diffusers with high pump efficiency; however, high efficiency does not mean low hemolysis. It seems important to prevent generation of small-sized eddies with high shear stress. Hemolysis tests are carried out to find the optimal vane profile and gap clearance. The index of hemolysis and temperature change of our pump is better than those of the Biopump. Short-term in vivo studies show that the layer of white thrombi adheres to the machined rough surface of polycarbonate, which composes the narrow gap (0.2 mm) between the impeller and the pump wall, but a smooth surface coated with silicon prevents adhesion of that layer.
我们一直在研发一种带有磁悬浮叶轮的离心血泵。为了提高泵的效率，我们研究了多种叶轮叶片和扩散器的泵性能，以及叶轮圆盘与泵壳之间间隙中的流动情况。我们找到了具有高泵效率的叶片和扩散器；然而，高效率并不意味着低溶血率。防止产生具有高剪切应力的小尺寸涡流似乎很重要。进行溶血试验以找到最佳的叶片轮廓和间隙。我们的泵的溶血指数和温度变化优于生物泵。短期体内研究表明，白色血栓层附着在构成叶轮与泵壁之间狭窄间隙（0.2毫米）的聚碳酸酯加工粗糙表面上，但涂有硅的光滑表面可防止该层的附着。
