Kobayashi S, Nitta S, Yambe T, Naganuma S, Hashimoto H, Fukuju T, Tabayashi K
Department of Medical Engineering and Cardiology, Tohoku University School of Medicine, Sendai, Japan.
Artif Organs. 1995 Jul;19(7):704-7. doi: 10.1111/j.1525-1594.1995.tb02408.x.
To estimate the effect of oscillated blood flow on hemodynamics in an awake condition, left ventricular assist circulation using oscillated blood flow was performed on 3 adult goats as chronic animal examination. A vibrating flow pump (VFP) was used for generating high-frequency oscillated flow. The blood flow rate of assisted circulation was approximately 1.0 L/min, and the driving frequency of VFP was 25 Hz. Systemic vascular resistance and arterial impedance were calculated in this study. Systemic vascular resistance during assist circulation was decreased compared with that without assistance. Oscillated blood flow may be effective in decreasing vascular resistance. Moreover, it was suggested from the study of arterial impedance that motive characteristics of the vascular wall against changing blood pressure may keep their normal reaction. Therefore, oscillated blood flow may be used for left ventricular assist circulation as concluded from the study of the characteristics of blood vessels.
为评估振荡血流对清醒状态下血流动力学的影响，对3只成年山羊进行了使用振荡血流的左心室辅助循环作为慢性动物实验。使用振动流泵（VFP）产生高频振荡流。辅助循环的血流量约为1.0升/分钟，VFP的驱动频率为25赫兹。本研究计算了全身血管阻力和动脉阻抗。与无辅助时相比，辅助循环期间的全身血管阻力降低。振荡血流可能在降低血管阻力方面有效。此外，从动脉阻抗研究表明，血管壁对血压变化的动力特性可能保持其正常反应。因此，根据血管特性研究得出结论，振荡血流可用于左心室辅助循环。
