Yamada K M, Miyamoto S
Laboratory of Developmental Biology NIDR, NIH, Bethesda, MD 20892-4370, USA.
Curr Opin Cell Biol. 1995 Oct;7(5):681-9. doi: 10.1016/0955-0674(95)80110-3.
Integrins are remarkably multifunctional: they mediate cell adhesion and migration, orchestrate organization of the actin-based cytoskeleton, and activate signal transduction pathways. Recent studies have identified a variety of steps and hierarchies in these intracellular cytoskeletal and signaling responses, laying the groundwork for future studies on specificity and coordination with responses to growth factors.
它们介导细胞黏附和迁移，协调基于肌动蛋白的细胞骨架的组织，并激活信号转导通路。最近的研究已经确定了这些细胞内细胞骨架和信号反应中的各种步骤和层次结构，为未来关于特异性以及与生长因子反应的协调的研究奠定了基础。
