Huttenlocher A, Sandborg R R, Horwitz A F
Department of Cell and Structural Biology, University of Illinois, Urbana, 61801, USA.
Curr Opin Cell Biol. 1995 Oct;7(5):697-706. doi: 10.1016/0955-0674(95)80112-x.
Adhesive interactions play a central role in cell migration. The regulation of these interactions requires the coordination of a multiplicity of signals, both spatially and temporally. The role of the integrin family has received considerable recent attention. Progress has been made in the elucidation of the mechanisms by which growth factors and other motogenic factors stimulate migration. Major advances have also been made in understanding the mechanisms by which the formation and breakdown of adhesive complexes are regulated, including the participation of members of the rho family. Despite these advances, many important questions remain, and the field seems well positioned to answer them.
黏附相互作用在细胞迁移中起着核心作用。这些相互作用的调节需要在空间和时间上协调多种信号。整合素家族的作用最近受到了相当多的关注。在阐明生长因子和其他促迁移因子刺激迁移的机制方面取得了进展。在理解黏附复合物形成和分解的调节机制方面也取得了重大进展，包括rho家族成员的参与。尽管取得了这些进展，但仍有许多重要问题存在，而且该领域似乎有能力回答这些问题。
