Abramo F, Bo S, Canese M G, Poli A
Department of Animal Pathology, University of Pisa, Italy.
AIDS Res Hum Retroviruses. 1995 Oct;11(10):1247-53. doi: 10.1089/aid.1995.11.1247.
Neuropathological examination of the central nervous system of 13 naturally and 13 experimentally feline immunodeficiency virus (FIV)-infected cats revealed diffuse gliosis of gray and white matter and vacuolar myelinopathy in a large proportion of infected animals, sometimes associated with lymphocytic meningitis. Multinucleated giant cell formation, the hallmark of multifocal giant cell encephalitis in HIV infection, was never observed. Morphometric analysis confirmed a marked increase of GFAP reactivity in infected cats. Gliosis was mainly present in cortical structures of frontal, parietal, and occipital lobes. Only one naturally infected animal evidenced clinical symptoms of neurological damage. This study confirms that FIV provides an interesting model for studying HIV-induced cortical and subcortical brain pathology believed to be the cause of the neurological manifestations frequently observed in AIDS patients.
对13只自然感染和13只实验感染猫免疫缺陷病毒（FIV）的猫的中枢神经系统进行神经病理学检查发现，在大部分受感染动物中，灰质和白质出现弥漫性胶质增生以及空泡性髓鞘病，有时伴有淋巴细胞性脑膜炎。从未观察到多核巨细胞形成，而多核巨细胞形成是HIV感染中多灶性巨细胞性脑炎的标志。形态计量分析证实，受感染猫的GFAP反应性显著增加。胶质增生主要出现在额叶、顶叶和枕叶的皮质结构中。只有一只自然感染的动物出现了神经损伤的临床症状。这项研究证实，FIV为研究HIV诱导的皮质和皮质下脑病理学提供了一个有趣的模型，这种病理学被认为是艾滋病患者经常观察到的神经表现的原因。
