Bolt H M, Laib R J, Kappus H, Buchter A
Toxicology. 1977 Apr;7(2):179-88. doi: 10.1016/0300-483x(77)90063-4.
When rats are exposed to [14C]vinyl chloride in a closed system, the vinyl chloride present in the atmosphere equilibrates with the animals' organism within 15 min. The course of equilibration could be determined using rats which had been given 6-nitro-1,2,3-benzothiadiazole. This compound completely blocks metabolism of vinyl chloride. The enzymes responsible for metabolism of vinyl chloride are saturated at an atmospheric concentration of vinyl chloride of 250 ppm. Pharmacokinetic analysis shows that no significant cumulation of vinyl chloride or its major metabolites is to be expected on repeated administration of vinyl chlorides. This may be consistent with the theory that a reactive, shortly living, metabolite which occurs in low concentration only, may be responsible for the toxic effects of vinyl chloride.
当大鼠在封闭系统中接触[14C]氯乙烯时，大气中存在的氯乙烯在15分钟内与动物机体达到平衡。可以使用给予6-硝基-1,2,3-苯并噻二唑的大鼠来确定平衡过程。该化合物完全阻断氯乙烯的代谢。负责氯乙烯代谢的酶在250 ppm的大气氯乙烯浓度下达到饱和。药代动力学分析表明，反复给予氯乙烯后，预计不会有氯乙烯或其主要代谢物的显著蓄积。这可能与以下理论一致，即仅以低浓度出现的反应性、寿命短的代谢物可能是氯乙烯毒性作用的原因。
