氯乙烯和偏二氯乙烯在哺乳动物体内的代谢比较及其致癌潜力
Comparative mammalian metabolism of vinyl chloride and vinylidene chloride in relation to oncogenic potential.
作者信息
Hathway D E
出版信息
Environ Health Perspect. 1977 Dec;21:55-9. doi: 10.1289/ehp.772155.
Abstract
Elucidation of the role of vinyl chloride metabolites in the various reaction sequences which comprise the metabolic pathway, including the interaction of reactive metabolities with some purine and pyrimidine residues of target-organ DNA, provides some explanation for the (oncogenic) properties associated with the original substance. Comparative investigation of the biological fate of vinylidene chloride reveals an agent of low oncogenic potential which is likely to be damaging only under special circumstances, and species differences which suggest that the mouse is more susceptible than the rat towards vinylidene chloride oncogenicity.
摘要
阐明氯乙烯代谢物在构成代谢途径的各种反应序列中的作用，包括活性代谢物与靶器官DNA的一些嘌呤和嘧啶残基的相互作用，为与原始物质相关的（致癌）特性提供了一些解释。对偏二氯乙烯生物命运的比较研究揭示了一种致癌潜力较低的物质，它可能仅在特殊情况下具有损害性，以及种属差异，这表明小鼠比大鼠对偏二氯乙烯致癌性更敏感。
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