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氯乙烯和偏二氯乙烯在哺乳动物体内的代谢比较及其致癌潜力

Comparative mammalian metabolism of vinyl chloride and vinylidene chloride in relation to oncogenic potential.

作者信息

Hathway D E

出版信息

Environ Health Perspect. 1977 Dec;21:55-9. doi: 10.1289/ehp.772155.

DOI:10.1289/ehp.772155
PMID:612460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1475329/
Abstract

Elucidation of the role of vinyl chloride metabolites in the various reaction sequences which comprise the metabolic pathway, including the interaction of reactive metabolities with some purine and pyrimidine residues of target-organ DNA, provides some explanation for the (oncogenic) properties associated with the original substance. Comparative investigation of the biological fate of vinylidene chloride reveals an agent of low oncogenic potential which is likely to be damaging only under special circumstances, and species differences which suggest that the mouse is more susceptible than the rat towards vinylidene chloride oncogenicity.

摘要

阐明氯乙烯代谢物在构成代谢途径的各种反应序列中的作用，包括活性代谢物与靶器官DNA的一些嘌呤和嘧啶残基的相互作用，为与原始物质相关的（致癌）特性提供了一些解释。对偏二氯乙烯生物命运的比较研究揭示了一种致癌潜力较低的物质，它可能仅在特殊情况下具有损害性，以及种属差异，这表明小鼠比大鼠对偏二氯乙烯致癌性更敏感。

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Environ Health Perspect. 1977 Dec;21:55-9. doi: 10.1289/ehp.772155.
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本文引用的文献

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Inactivation of bacteriophage T7 by mono- and difunctional sulphur mustards in relation to cross-linking and depurination of bacteriophage DNA.单功能和双功能硫芥对噬菌体T7的灭活作用与噬菌体DNA的交联和脱嘌呤作用的关系
J Mol Biol. 1969 Jan 14;39(1):181-98. doi: 10.1016/0022-2836(69)90341-6.
2
Fluorescent adenosine and cytidine derivatives.荧光腺苷和胞苷衍生物
Biochem Biophys Res Commun. 1972 Jan 31;46(2):597-604. doi: 10.1016/s0006-291x(72)80181-5.
3
The biological fate in rats of vinyl chloride in relation to its oncogenicity.氯乙烯在大鼠体内的生物学归宿及其致癌性
Chem Biol Interact. 1975 Dec;11(6):545-62. doi: 10.1016/0009-2797(75)90030-7.
4
Liver-microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride.肝脏微粒体介导的由溴乙烯和氯乙烯形成烷基化剂的过程。
Biochem Biophys Res Commun. 1975 Nov 17;67(2):596-603. doi: 10.1016/0006-291x(75)90854-2.
5
Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxiran formation.作为代谢环氧乙烷形成的函数，氯乙烯的体外诱变性和潜在致癌性。
Biochem Pharmacol. 1975 Nov 1;24(21):2013-7. doi: 10.1016/0006-2952(75)90396-2.
6
Human, rat and mouse liver-mediated mutagenicity of vinyl chloride in S. typhimurium strains.人、大鼠和小鼠肝脏介导的氯乙烯在鼠伤寒沙门氏菌菌株中的致突变性。
Int J Cancer. 1975 Mar 15;15(3):429-37. doi: 10.1002/ijc.2910150309.
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Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide.氯乙醛的致突变性，氯乙醛是1,2 - 二氯乙烷（二氯化乙烯）、氯乙醇（氯乙醇）、氯乙烯和环磷酰胺的一种可能代谢产物。
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Ann N Y Acad Sci. 1975 Jan 31;246:258-67. doi: 10.1111/j.1749-6632.1975.tb51101.x.
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Cytochrome P-450 and the metabolism of vinyl chloride.细胞色素P - 450与氯乙烯的代谢
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