Loeser E, Lorke D
Toxicology. 1977 Apr;7(2):225-32. doi: 10.1016/0300-483x(77)90068-3.
Cadmium in the form of CdCl2 was administered with the feed in concentrations of 0, 1, 3, 10 and 30 ppm over a period of 3 months to groups of 2 male and 2 female beagle dogs each. The appearance, behaviour food consumption, growth and mortality of the treated dogs in all groups was not affected. In the groups up to 30 ppm cadmium caused no detectable harm to blood, liver or kidneys. The systolic and diastolic blood pressure of the treated animals of all groups up to 30 ppm was within the normal range. The autopsies and histopathological investigations revealed no evidence of any damage. Cadmium accumulated dose-dependently above all in the kidneys and liver. The dogs tolerated concentrations of up to 30 ppm cadmium in their feed over a period of 3 months without harm.
以氯化镉（CdCl₂）形式存在的镉，以0、1、3、10和30 ppm的浓度混入饲料中，对每组2只雄性和2只雌性比格犬进行为期3个月的投喂。所有组中受试犬的外观、行为、食物消耗、生长和死亡率均未受到影响。在镉含量达30 ppm的各组中，未对血液、肝脏或肾脏造成可检测到的损害。镉含量达30 ppm的所有组中受试动物的收缩压和舒张压均在正常范围内。尸检和组织病理学调查未发现任何损伤迹象。镉尤其是在肾脏和肝脏中呈剂量依赖性蓄积。这些犬在3个月的时间里耐受了饲料中高达30 ppm的镉浓度，未受伤害。
