Agaev I N
Vopr Onkol. 1977;23(2):33-7.
Under study were the content of serotonin and 11-OCS in blood and diurnal excretion of 5-OIAA, adrenaline and noradrenaline in 71 pateints with breast cancer. The data obtained indicated that the examined patients, compared with the control group, show a reliably higher concentration of serotonin and 11-OCS in blood (70.4% and 19.5% correspondingly), an insignificantly increased excretion of 5-OIAA, a markedly increased diurnal excretion of adrenaline (by 96.4%), whereas a decreased excretion of noradrenaline (by 73.1%). The character of changes in the indices under study was definitely dependent on the stage of the disease (in stages 1-11 these changes were mostly pronounced), and patients' age (in young patients the adrenal cortex activity was rather intensive, whereas in aged patients biologically active substances were manifest).
对71例乳腺癌患者血液中血清素和11-氧皮质类固醇的含量以及5-羟吲哚乙酸、肾上腺素和去甲肾上腺素的日间排泄情况进行了研究。获得的数据表明，与对照组相比，所检查的患者血液中血清素和11-氧皮质类固醇的浓度可靠地更高（分别为70.4%和19.5%），5-羟吲哚乙酸的排泄略有增加，肾上腺素的日间排泄显著增加（增加了96.4%），而去甲肾上腺素的排泄减少（减少了73.1%）。所研究指标的变化特征肯定取决于疾病阶段（在1-11期这些变化最为明显）以及患者年龄（年轻患者肾上腺皮质活动相当活跃，而老年患者生物活性物质表现明显）。
