Biglioli P, Spirito R, Pompilio G, Agrifoglio M, Sala A, Arena V, Sisillo E
Department of Cardiac Surgery, Centro Cardiologico I. Monzino Foundation, Milan, Italy.
Cardiovasc Surg. 1995 Oct;3(5):511-8. doi: 10.1016/0967-2109(09)67210-c.
Forty-six patients who had had an elective repair of a descending thoracic aortic aneurysm were reviewed, in order to investigate the efficacy of support by a centrifugal pump on distal organ perfusion and spinal cord protection during cross-clamping of the thoracic aorta. Two concurrent groups were analysed: 36 patients (78%) were supported by left atriofemoral arterial bypass with a centrifugal pump and 10 (22%) had no distal circulatory support. No patient was fully heparinized. The demographic data and preoperative characteristics of the groups, including location and type of aneurysm, were similar. The mean(s.d.) duration of cross-clamping was 37.8 (16) min in the centrifugal pump group and 42.3(21) min in the simple clamping group. Preoperative haemodynamic and laboratory data were similar in both groups. During cross-clamping, parameters of pH and blood urea varied but were better in the centrifugal pump group; changes from pre-intervention to early aortic cross-clamping time were not significant (pH, P < 0.0006; bases, P < 0.0003). Differences in creatinine values were caused mainly by the change from pre-intervention to the first postoperative day (P < 0.03); this continued throughout the hospital stay. The cerebrospinal fluid pressure measurement indicated a significant difference in time change (P < 0.0001) and mean level over time (P < 0.0002): levels were significantly lower in the centrifugal pump group throughout aortic cross-clamping. Three patients in the simple clamping group and none in the centrifugal pump group (P < 0.02) required cerebrospinal fluid drainage.(ABSTRACT TRUNCATED AT 250 WORDS)
对46例行择期降主动脉瘤修复术的患者进行了回顾性研究,以探讨离心泵支持在胸主动脉阻断期间对远端器官灌注及脊髓保护的效果。分析了两个同期组:36例患者(78%)接受离心泵辅助的左心房-股动脉旁路支持,10例患者(22%)未接受远端循环支持。所有患者均未充分肝素化。两组患者的人口统计学数据及术前特征相似,包括动脉瘤的位置和类型。离心泵组的平均(标准差)主动脉阻断时间为37.8(16)分钟,单纯阻断组为42.3(21)分钟。两组术前的血流动力学和实验室数据相似。在主动脉阻断期间,pH值和血尿素参数有所变化,但离心泵组情况更好;干预前至主动脉早期阻断时的变化不显著(pH值,P<0.0006;碱,P<0.0003)。肌酐值的差异主要由干预前至术后第1天的变化引起(P<0.03);在整个住院期间这种差异持续存在。脑脊液压力测量显示时间变化(P<0.0001)及随时间的平均水平(P<0.0002)存在显著差异:在整个主动脉阻断期间,离心泵组的脑脊液压力水平显著更低。单纯阻断组有3例患者需要脑脊液引流,离心泵组无患者需要(P<0.02)。(摘要截选至250词)