癌症易感性。处于十字路口的共济失调毛细血管扩张症。
Cancer predisposition. Ataxia-telangiectasia at the crossroads.
作者信息
Jackson S P
机构信息
Wellcome/Cancer Research Campaign Institute, Cambridge University, UK.
出版信息
Curr Biol. 1995 Nov 1;5(11):1210-2. doi: 10.1016/s0960-9822(95)00238-7.
PMID:8574569
Abstract
ATM, the gene product mutated in the cancer susceptibility syndrome ataxia-telangiectasia, is related to proteins involved in DNA repair and cell-cycle control, perhaps explaining how ATM prevents carcinogenesis.
摘要
ATM是在癌症易感性综合征共济失调毛细血管扩张症中发生突变的基因产物，它与参与DNA修复和细胞周期控制的蛋白质有关，这或许可以解释ATM是如何预防癌症发生的。
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